Creative Biolabs released cell-free membrane protein expression service for protein related research.
Membrane proteins occupy one fourth of total encoding genes in genome. They localize on the cell membrane, play various roles such as signal transduction, transportation and ligand-binding. It is estimated more than half of the drug candidates target membrane proteins, mainly G-protein coupled receptors (GPCRs) and ion channels. However, due to the nature of membrane protein, traditional protein expression methods encounter obstacles such as low amount of expression, inadequate post-translational modification, misfolding, and loss of bio-activity.
Aiming to solve the problems in the conventional methods, Creative Biolabs designs a novel cell-free membrane protein expression system. In this unique system, the neonatal membrane protein inserts into liposome, which is well designed to imitate the in vivo membrane features, keeping the native conformation and bio-activity to the greatest extent.
The cell-free expression system also possesses other advantages: high purity of target protein, rapid and stable expression, high yield and good repeatability. The system is also easy to be adapted to diverse requirement from our clients, such as the size and modification of liposome, the therapeutics encapsuled in the liposome and type of solvent reagents. Our system is tailored for customers in membrane protein projects of antibody screening, ligand discovery, drug delivery, vaccine development, and structural determination.
About Creative Biolabs
Creative Biolabs is specialized in providing custom biotechnology and pharmaceutical services that cover the full scope of biotechnology needs of early drug discovery and drug development. As a trusted provider of the most cost-effective outsourcing solutions, Creative Biolabs has been working for a large number of satisfied clients from biotechnology and pharmaceutical companies as well as government and academic research laboratories all over the world. It was founded by scientists who are dedicated to the conquering of cancer. We believe to build up a custom-service-centered business model is important for optimizing the drug development process, leveraging accessible resources, and forming a team of various background to conduct drug discovery in future. Our commitment to this long-term goal motivates us to deliver the highest quality results to our clients with speed.