Creative
Biolabs released cell-free membrane protein expression
service for protein related research.
Membrane
proteins occupy one fourth of total encoding genes in genome. They localize on
the cell membrane, play various roles such as signal transduction,
transportation and ligand-binding. It is estimated more than half of the drug
candidates target membrane proteins, mainly G-protein coupled receptors
(GPCRs) and ion
channels. However, due to the nature of membrane protein, traditional protein
expression methods encounter obstacles such as low amount of expression,
inadequate post-translational modification, misfolding, and loss of
bio-activity.
Aiming
to solve the problems in the conventional methods, Creative Biolabs designs
a novel cell-free membrane protein expression system. In this unique
system, the neonatal membrane protein inserts into liposome, which is well
designed to imitate the in vivo membrane features, keeping
the native conformation and bio-activity to the greatest extent.
The cell-free expression system
also possesses other advantages: high purity of target protein, rapid and
stable expression, high yield and good repeatability. The system is also easy
to be adapted to diverse requirement from our clients, such as the size and
modification of liposome, the therapeutics encapsuled in the liposome and type
of solvent reagents. Our system is tailored for customers in membrane protein
projects of antibody screening, ligand discovery, drug delivery, vaccine
development, and structural determination.
About
Creative Biolabs
